Alfred L George Selected Research

Atrial Fibrillation

1/2024	Engineered cocultures of iPSC-derived atrial cardiomyocytes and atrial fibroblasts for modeling atrial fibrillation.
11/2014	SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation.
4/2008	Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation.
12/2007	Structural models for the KCNQ1 voltage-gated potassium channel.

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Alfred L George Research Topics

Disease

29	Cardiac Arrhythmias (Arrythmia) 05/2024 - 01/2002
27	Epilepsy (Aura) 04/2024 - 12/2003
18	Long QT Syndrome 01/2021 - 01/2002
13	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2019 - 12/2003
9	Seizures (Absence Seizure) 04/2024 - 12/2005
8	Brain Diseases (Brain Disorder) 11/2023 - 10/2014
8	Neurodevelopmental Disorders 11/2023 - 10/2014
6	Sudden Death 03/2024 - 03/2008
5	Cardiovascular Diseases (Cardiovascular Disease) 11/2021 - 03/2008
5	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 03/2002
5	Migraine Disorders (Migraine) 01/2021 - 07/2008
5	Generalized Epilepsy with Febrile Seizures Plus 11/2010 - 06/2002
4	Atrial Fibrillation 01/2024 - 12/2007
4	Brugada Syndrome 05/2022 - 01/2002
4	Channelopathies 01/2021 - 08/2005
4	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2020 - 04/2011
4	Torsades de Pointes (Torsade de Pointes) 01/2013 - 02/2012
4	Sudden Infant Death (SID) 03/2008 - 01/2007
3	Cardiomyopathies (Cardiomyopathy) 05/2024 - 11/2007
3	Fetal Death 01/2019 - 04/2013
3	Pain (Aches) 06/2017 - 04/2009
3	Ventricular Tachycardia 04/2017 - 07/2004
3	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2017 - 02/2008
3	Drug-Related Side Effects and Adverse Reactions 01/2016 - 01/2002
3	Hypertension (High Blood Pressure) 04/2014 - 11/2007
3	Myotonia Congenita (Thomsen Disease) 10/2013 - 12/2002
3	Epileptic Syndromes 10/2006 - 06/2002
2	Autistic Disorder (Autism) 04/2024 - 10/2014
2	Disease Susceptibility (Diathesis) 05/2022 - 01/2022
2	Nervous System Diseases (Neurological Disorders) 01/2022 - 11/2010
2	Alternating hemiplegia of childhood 01/2020 - 01/2018
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2019 - 12/2005
2	Ventricular Fibrillation 08/2017 - 02/2014
2	Polymorphic catecholergic ventricular tachycardia 06/2014 - 03/2014
2	Heart Arrest (Cardiac Arrest) 03/2013 - 07/2004
2	Myocardial Infarction 07/2012 - 04/2011
2	Myotonia 03/2011 - 01/2004
2	Myotonic Disorders (Paramyotonia Congenita) 03/2011 - 01/2004
2	Migraine with Aura (Familial Hemiplegic Migraine) 11/2010 - 07/2008
2	Deafness (Deaf Mutism) 12/2007 - 10/2007
2	Paralysis (Palsy) 04/2006 - 09/2002
2	Febrile Seizures (Febrile Seizure) 07/2004 - 12/2003
2	Generalized Epilepsy 07/2004 - 12/2003
1	Scoliosis 04/2024
1	Vision Disorders (Hemeralopia) 04/2024
1	Premature Cardiac Complexes (Extrasystoles) 01/2023
1	Bradycardia 01/2023
1	Status Epilepticus (Complex Partial Status Epilepticus) 11/2022
1	Major Depressive Disorder (Major Depressive Disorders) 01/2022
1	Developmental Disabilities (Developmental Disability) 01/2022
1	Autism Spectrum Disorder 01/2021
1	Spasm (Spasms) 01/2021
1	Heart Diseases (Heart Disease) 11/2020

Drug/Important Bio-Agent (IBA)

29	Sodium Channels (Sodium Channel)IBA 05/2022 - 10/2003
22	Voltage-Gated Sodium ChannelsIBA 04/2024 - 01/2002
17	SodiumIBA 03/2024 - 01/2004
12	Ion Channels (Ion Channel)IBA 01/2022 - 08/2005
11	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2023 - 03/2013
8	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2005
7	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 01/2022 - 10/2007
5	Anti-Arrhythmia AgentsIBA 01/2024 - 01/2004
4	6- (4- (trifluoromethoxy)phenyl)- 3- (trifluoromethyl)(1,2,4)triazolo(4,3- a)pyridineIBA 01/2018 - 08/2014
4	Chloride Channels (Chloride Channel)IBA 10/2013 - 03/2002
3	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021 - 01/2017
3	Sodium Channel BlockersIBA 01/2020 - 01/2017
3	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 04/2002
3	PotassiumIBA 01/2016 - 09/2002
3	Ranolazine FDA Link 01/2014 - 11/2010
3	Propranolol (Inderal)FDA LinkGeneric 03/2012 - 12/2008
3	Potassium Channels (Potassium Channel)IBA 02/2012 - 03/2008
2	Mexiletine (Mexitil)FDA LinkGeneric 11/2020 - 01/2004
2	Adenosine Triphosphatases (ATPase)IBA 01/2020 - 01/2018
2	Messenger RNA (mRNA)IBA 01/2020 - 12/2002
2	KCNQ1 Potassium ChannelIBA 01/2019 - 10/2017
2	RNA (Ribonucleic Acid)IBA 01/2017 - 02/2014
2	ChloridesIBA 01/2016 - 01/2008
2	NucleotidesIBA 10/2014 - 01/2007
2	Ether (Diethyl Ether)IBA 11/2012 - 08/2004
2	beta Adrenergic ReceptorsIBA 03/2012 - 03/2002
2	SaltsIBA 11/2007 - 03/2005
1	FilaminsIBA 05/2024
1	Proteasome Endopeptidase Complex (Proteasome)IBA 05/2024
1	Bortezomib (Velcade)FDA Link 05/2024
1	Epinephrine (Adrenaline)FDA LinkGeneric 01/2023
1	Glutamic Acid (Glutamate)FDA Link 01/2023
1	Caffeine (No Doz)FDA LinkGeneric 01/2023
1	Midazolam (Versed)FDA LinkGeneric 11/2022
1	Fluoxetine (Prozac)FDA LinkGeneric 01/2022
1	Escitalopram FDA Link 01/2022
1	NAV1.2 Voltage-Gated Sodium ChannelIBA 01/2022
1	ezogabine (retigabine)IBA 01/2022
1	Sertraline (Zoloft)FDA LinkGeneric 01/2022
1	Citalopram FDA LinkGeneric 01/2022
1	Biomarkers (Surrogate Marker)IBA 11/2021
1	Calcium-Activated Potassium Channels (Calcium-Activated Potassium Channel)IBA 01/2021

Therapy/Procedure

10	Therapeutics 10/2022 - 07/2004
2	Precision Medicine 10/2022 - 11/2018
2	Drug Therapy (Chemotherapy) 04/2011 - 01/2002
1	Gastrostomy 04/2024
1	Length of Stay 01/2022